Mexico, MO – Fatal Multi-Vehicle Crash on MO-22 W of Rte E

Mexico, MO (January 22, 2026) – A fatal multi-vehicle crash was reported Wednesday morning, January 21, on Missouri 22 about 1.5 miles west of Route E in Audrain County. One driver was killed, and two others were injured in the early morning incident.

The crash happened around 6:45 a.m. The Missouri State Highway Patrol reported that the fatal multi-vehicle crash involved a 2010 Ford Escape and a 2023 Freightliner, both heading west on Missouri 22. The incident occurred when the Ford Escape attempted to pass multiple vehicles. During the maneuver, the Ford struck an eastbound 2019 Kenworth in a head-on offset impact.

Following the collision, the Freightliner left the roadway and overturned, coming to rest on its roof. The Ford Escape came to rest partially in the eastbound lane and on the shoulder. The Kenworth traveled off the roadway and caught fire.

The 35-year-old male driver of the Ford Escape was ejected during the crash and was pronounced dead at the scene. He was not wearing a safety device at the time of the wreck. The driver of the Freightliner, a 56-year-old man, suffered moderate injuries and was taken to a hospital for treatment.

The 46-year-old driver of the Kenworth sustained moderate injuries but declined medical transport at the scene. Emergency units responded and secured the area while assisting those involved.

The investigation into the cause of the collision is ongoing. 

Our deepest condolences go out to the family of the victim who passed away. We also wish the drivers who were injured a swift and complete recovery.

Why Head-On Crashes in Mexico, MO Carry Serious Risks

Head-on crashes on two-lane highways are among the most dangerous roadway accidents. Roads like Missouri 22 near Mexico often have limited passing zones, narrow shoulders, and little separation between opposing lanes of traffic. When a driver attempts to pass without enough distance or misjudges the speed of oncoming vehicles, the risk of a severe collision rises sharply. These highways may appear quiet at times, but even a brief error can have serious consequences.

Crashes involving opposing traffic often lead to serious injuries or fatalities because of the combined force of two vehicles moving toward each other. Drivers and passengers may suffer head injuries, chest trauma, broken bones, or internal injuries. In some cases, occupants can be ejected from the vehicle, which significantly increases the risk of death. Fires after a crash can also worsen outcomes, even when emergency responders arrive quickly.

We help people understand how injury and fatal crash cases are commonly handled. Our team has experience reviewing crash reports, insurance policies, and medical records to explain what options may be available. A car accident attorney can help clarify how compensation may apply and what steps can be taken based on the facts of a specific case.

If you are unsure of what to do after a serious highway crash, you can contact Dunk Law Firm at 414-209-4398. We can explain how these cases are typically reviewed and discuss possible next steps.

Note: This post is based on information obtained from publicly available secondary sources. We have not independently verified all details of the incident. If you notice any inaccuracies or missing information, please contact Dunk Law Firm so we can promptly review and correct the content for accuracy and reliability.

Disclaimer: The content of this post is for general informational purposes only and should not be construed as legal or medical advice. It does not create an attorney-client relationship nor constitute a solicitation for legal services. If you have been injured in an accident, please seek immediate medical attention and consult a qualified attorney. Any images included are for illustrative purposes only and do not represent the actual scene or parties involved in the incident.